By December 17, 2017 July 17th, 2019 Prohormones

What is Epistane (Methylepitiostanol)

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Epistane is a prohormone that can be ingested orally. It resembles the dihydrotestosterone (DHT), which is a male sex hormone said to slow down baldness. Bodybuilders just refer to this non-progestanic substance as “Epi.” It works by binding itself to the androgen receptors in the cells found in your muscles. After enhancing levels of protein and nitrogen, it will help build muscle mass, as well as boost your strength. It is not designed to aromatize, which means it won’t convert the testosterone into estrogen that can lead to bloating, water retention and fat gain. For comparison’s sake, you can probably liken Epistane to Winstrol or Turinabol.

As prohormones go, Epistane is not the oldest. In fact, it wasn’t until 1966 when Japanese researchers stumbled upon the compound. When it was launched in the market, it assumed the name methepistiostane and was billed as an effective drug against breast cancer. As always with prohormones, bodybuilders recognized its benefits due to an 1100:91 ratio of anabolic to androgenic. It wasn’t until the mid-2000s, however, when the compound was introduced as a supplement for bodybuilders.

Chemical Structure:  2a,3a-epithio-17a-methyl-5a-androstan-17b-ol

How to Cycle Epistane

The good thing about this product is that it works well with any anabolic steroids when you decide to stack. So regardless if you are using Trenbolone, Deca Durabolin, Testosterone, Dianabol or Trenavar, you are good to go. You can also take Epistane on its own, particularly for newbies whose bodies have never been exposed to steroids. Those who have completed about four cycles will find the benefits of stacking Epistane with other hormones for cutting or weight loss.

Even if you diet, the muscle mass can still be retained. This is ideal for cutting because only the fat will be burned to augment the caloric deficit. On recomp cycles, you can stack the compound with a combination of Trenavar and PrimobolDx (Methyl-diaz) to boost protein synthesis and nitrogen, while converting fat into energy.

Because of its very minimal toxicity profile, Epistane is great for stacking with halodrol (to gain dry hard muscles) or mythelstenbolone for quick mass gain and to harden the muscles that are already gained.

For newbies, it is recommended that you take just 30mg daily. For capsules with 10mg and average half-life, it means you have to take it three times every seven hours. The first capsule is taken upon waking up. You should also ingest a pill an hour before working out. You do this for the next four weeks. For those with experience, they can increase the dosage to 40mg daily, which should last during the whole 6-week cycle.

Implement a post-cycle therapy immediately after taking the last of the Epistane pill. The PCT is crucial for your body to produce natural hormones once again, which has been messed up while you were on Epistane. You really don’t want to develop gynecomastia (female breast development) because you fail to monitor your intake. The rule of thumb is the longer the cycle and the higher the dosage, the bigger the risk of developing gyno. You can minimize the risk by not stopping abruptly the intake of Epistane, but rather to turn back down the amount of milligrams near the end of the cycle.

For best results, it is recommended that you use Nolvadex and creatinine for the PCT.

Side Effects of Epistane

Epistane is considered as a mild hormone, which means it doesn’t put as much burden on your liver compared to the other prohormones. Unlike steroids that can be very hard for the liver to break down, Epistane contains milder substances so you are sure that the liver does not actually take a beating when you take it in.

Among the things you should look out for are the negative effects to your blood pressure, good cholesterol and lipids. Users also complain of joint pains or lethargy. You may also experience declining sex drive, as well as hair loss. If you cycle at high doses, you will experience dry joints. You can offset this by taking the proper supplements. One of the reasons why this prohormone remains popular is because of its mild side effects. It is unlikely for you to have any acne outbreaks and you won’t be as aggressive. The hair loss is not reported by the majority of users so that’s always good news.

What’s great about Epistane is that it does not give off that many negative side effects unlike its other prohormone counterparts. You will not experience breakouts or a sudden rise of your blood pressure. When taken in mild dosages, Epistane is completely safe and effective. No wonder that it is one of the most popular supplements today in the fitness community in terms of getting the best hard look especially for those preparing for a competition.

At low dosages of 30-40mg in a span of three or four weeks, you should be okay. The key, therefore, is to never to abuse the drug by not taking them in high dosages. It should be noted, however, that those who used Epistane reported of better results on a cycle of six weeks.

Benefits of Using Epistane

Among the benefits of taking Epistane are:

  • Quick gaining of dry and lean muscles
  • Enhances strength levels allowing you to lift heavier weights
  • Boosts energy levels allowing you to perform more repetitions
  • Helps prevent unwanted fat
  • Little or no water retention

Chemical Name(s):

Synonyms: Epistane, Epi Plex, Havoc, Epi.


As you can see, Epistane is ideal for those who are new to the arcane world of bodybuilding and muscle gain. Its low level of toxicity means it can be stacked with other hormones and anabolic steroids, not to mention that it is safe to use. It is also very flexible in the sense that it can be used for quickly gaining solid mass or for cutting, depending on how you stack and cycle.

Drug Class

Drug class AndrogenAnabolic steroid